Preparation of Magnetic Iron Oxide Incorporated Mesoporous Silica Hybrid Composites for pH and Temperature-Sensitive Drug Delivery

In clinical applications for cancer treatment, chemotherapy coupled with thermotherapy is highly considered. The development of multifunctional nanocomposite materials an appealing strategy use in various including biomedical applications. We present the preparation dopamine-modified mesoporous silica material, which magnetic iron oxide nanoparticles (FeNP) were grown onto outer surface via complexation (Fe(III) and Fe(II)) ions dopamine groups modified on hybrid subsequent chemical reduction approaches. prepared incorporated composite (FeNP@MSHC NPs) had a large area (346 m2/g), pore size (3.2 nm), volume (0.048 cm3/g). formation FeNP FeNP@MSHC NPs results superparamagnetic characteristics. Furthermore, have high drug (Dox) loading capacity (~62%) as well pH- temperature-responsive release efficiency. addition, MTT assay result shows biocompatibility NPs. As result, could be utilized treatment pH temperature-sensitive delivery chemotherapeutic agents to target sites.